Spike first discovered Drusilla after he was rejected of the Cecily; he fled the new class he was likely to, and you may sobbed into the the area alleyway. Drusilla, who’d made a decision to choose good playmate, sired him. The guy grew greatly connected to the woman, and soon after applauded their as the “your face from their salvation.” He had been devastated when he basic caught Drusilla having sexual intercourse that have Angelus.  Even though their thinking is actually left hardened consequently, he was able strong passion for her. Whenever she was left for the a weakened condition a virtually-death-come across in the Prague,  the guy looked for sanctuary on her behalf close to the Sunnydale Hellmouth; their head inspiration from inside the staying in Sunnydale would be to let their recover.
Increase briefly transported their soul so you can Drusilla to attempt to get his old love,  however, took it back when the guy acknowledged you to the woman sensitive rational county suggested she couldn’t deal with the newest shame considering having a heart
Saddened and you can jealous, Increase is caused to help you betray Angelus and you can refrain Sunnydale having Drusilla from inside the tow.  When you look at the Brazil, she cheated for the your once more, having a turmoil demon. But not, it absolutely was after showed that Drusilla had broken up with him since the owing to this lady visions she may see his stored fixation and very quickly to-be understood “feelings” to have Buffy just after the guy aided the lady inside the finishing Acathla and might perhaps not endure they when all the she noticed when she examined your was the newest Slayer.  Spike returned to Sunnydale later to track down a romance concoction, but later on changed their attention and you can felt like you to torturing this lady perform earn the lady back, even though one to also hit a brick wall. 
Immediately following Angel missing his spirit and rejoined her or him, Drusilla resumed an intimate relationship with this lady sire once more
A processor chip-inserted Increase do afterwards discuss the lady while in the an unsuccessful suicide shot, stating “Goodbye, Dru. See you into the Hell.”  Whenever discussing their were not successful reference to Drusilla with Anya Jenkins, Spike stated that they must destroy the lovers once the payback. However, whenever Anya rejected, Increase is actually reluctant to really share Dru, as he did however love the lady.  When Xander had admitted so you can Spike not everyone knew their interest in Anya, Increase said he might relate and you can reminisced over his prior matchmaking having Drusilla, claiming “Not one person previously really had Dru, y’know?” 
Drusilla returned to Sunnydale throughout the expectations of reforming the “family.” Spike looked fascinated and you will chosen a few of his thinking on her, briefly deciding to incorporate the girl and have back into the new means he had been. Just after serving a dead person and you may slamming out Buffy, Spike out of the blue turned-on Drusilla and tied up xmeeting him or her one another as much as decide completely. Creating his brain fairly easily, Surge confessed their want to Buffy and you may desperately tried to persuade their it had been genuine. Drusilla suddenly chuckled at the your, revealing one to she had understood all the with each other he loved the woman since the due to the woman unique results. Whenever Buffy still would not get their thinking seriously, Increase increased aggravated and you will decided to stake Drusilla very she you are going to trust him. Then he indicated their turned affection of Drusilla and told you she meant a whole lot to help you him, saying she “spared your of mediocrity.” While Surge is actually distracted because of the Equilibrium, Drusilla was able to lay by herself free and you can attacked Buffy (who was simply still chained). Increase drawn the woman of her and protected Buffy. Watching in which his loyalties rest, an angry and you will upset Drusilla gave up with the Increase and you will leftover, seeing your while the far too “lost” for her to greatly help your. 
The two had been briefly reunited when Drusilla are rented by the Wolfram Hart to help their brand new mate, John, which went shortly after Spike in the distorted religion your vampire got stolen their spirit.  1st unwilling to look for the lady, Surge with knowing you to definitely Dru try poisonous and you will hazardous for his household members.  Spike following got Willow admit Drusilla on Mosaic Wellness Cardio.