Cox proportional danger models were used to estimate RRs and you can 95% CIs

Cox proportional danger models were used to estimate RRs and you can 95% CIs

RRs (95% CI) regarding complete, ischemic, and hemorrhagic shots by quintiles regarding mutual eating plan ratings having magnesium, potassium, and you can calcium consumption in 86,149 women in brand new NHS I and you can 94,715 feamales in the latest NHS II step one

We up-to-date the latest meta-analyses off potential degree from dietary magnesium ( 21), potassium ( 22), and you will calcium supplements ( Rate My Date dating site free 23) consumption and you will risk of heart attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

RRs (95% CI) off full, ischemic, and hemorrhagic shots because of the quintiles out-of joint eating plan score having magnesium, potassium, and you will calcium intakes during the 86,149 women in the brand new NHS I and you will 94,715 feamales in the latest NHS II 1

I up-to-date the brand new meta-analyses of potential degree out-of fat loss magnesium ( 21), potassium ( 22), and you can calcium supplements ( 23) consumption and you will threat of stroke

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.

I examined full and you may weightloss consumption each and every nutrient and risk out-of stroke to choose any potential nonlinear association that with limited cubic splines; although not, zero high departure out of linearity are noticed. Simultaneously, i searched the possibility feeling amendment from the ages, blood circulation pressure, otherwise diabetic issues into loved ones ranging from overall consumption of all the step three minerals and chance of complete coronary arrest. Zero high impact amendment try observed because of the such items.

Early in the day meta-analyses incorporated is a result of prior analyses regarding the NHS ( 10); these results was basically changed by the causes the current investigation. In addition, this new literature is appeared, and you can latest possible studies ( 8, 24) have been used in such updated meta-analyses. Zero between-studies heterogeneity was observed for any of your own step three nutritional elements. The fresh new shared RR out-of overall coronary arrest is 0.87 (95% CI: 0.83, 0.92) to have an one hundred-mg/d improve of magnesium intake, 0.91 (95% CI: 0.88, 0.94) to own good a thousand-mg/d boost of potassium intake, and you can 0.98 (95% CI: 0.94, step one.02) having a 3 hundred-mg/d raise from calcium intake.

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